Phenotypes Associated with This Genotype

Genotype
MGI:5448157

• Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv; Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:189962 )

• moribund within 35 days of birth

immune system

increased T cell proliferation ( J:189962 )

enlarged spleen ( J:189962 )

increased T cell number ( J:189962 )

• in the spleen and peripheral lymph node

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased regulatory T cell number ( J:189962 )

• in peripheral lymph node at day 20

• however, thymic and splenic regulatory T cell numbers are normal at day 12

abnormal regulatory T cell physiology ( J:189962 )

• regulatory T cells are not able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells unlike wild-type regulatory T cells

enlarged lymph nodes ( J:189962 )

increased interferon-gamma secretion ( J:189962 )

abnormal inflammatory response ( J:189962 )

• infiltrate of leukocytes in the salivary glands, lung interstitia, liver sinusoids, pancreas acini, stomach and colon mucosa

behavior/neurological

hunched posture ( J:189962 )

• lack of mobility associated with hunched posture

paralysis ( J:189962 )

• lack of mobility associated with hunched posture

integument

abnormal skin appearance ( J:189962 )

• crusting of the ears, eyelids and tail

limbs/digits/tail

abnormal tail morphology ( J:189962 )

• scurfy tail

hematopoietic system

increased T cell proliferation ( J:189962 )

enlarged spleen ( J:189962 )

increased T cell number ( J:189962 )

• in the spleen and peripheral lymph node

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• in the spleen and peripheral lymph nodes

increased regulatory T cell number ( J:189962 )

• in peripheral lymph node at day 20

• however, thymic and splenic regulatory T cell numbers are normal at day 12

abnormal regulatory T cell physiology ( J:189962 )

• regulatory T cells are not able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells unlike wild-type regulatory T cells

growth/size/body

enlarged spleen ( J:189962 )

cellular

increased T cell proliferation ( J:189962 )