Phenotypes Associated with This Genotype

Genotype
MGI:5447744

• Allelic Composition: Serpinb3a^tm1Gsil/Serpinb3a^tm1Gsil
• Genetic Background: C.129-Serpinb3a^tm1Gsil

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

decreased respiratory mucosa goblet cell number ( J:189949 )

• following house dust-mite challenge

decreased airway responsiveness ( J:189949 )

• house dust mite- or IL13-induced airway hyperresponsiveness is attenuated

• however, house dust mite-induced allergen sensitization and inflammation are normal

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:189949 )

• mice exposed to house dust mite exhibit attenuated airway hyperresponsiveness and reduced mucus-producing goblet cell hyperplasia compared with wild-type mice

• IL13-treated mice exhibit attenuated airway hyperresponsiveness, reduced inflammatory cells in the bronchoalveolar lavage fluid and reduced mucin production compared with wild-type mice

• however, house dust mite-induced allergen sensitization and inflammation are normal