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Phenotypes Associated with This Genotype
Genotype
MGI:5447068
Allelic
Composition
Tg(Neurod2-Smo*A2)#Jols/0
Genetic
Background
C57BL/6-Tg(Neurod2-Smo*A2)#Jols
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• radial glial cells in the cerebella exhibit disorganized, entangled glial processes at P5, P14 and P28
• impaired migration of granule neuron precursors in the cerebellum
• increased granule neuron precursor proliferation at P5, P14 and P28
• beginning at 2 months and increasing incidence with age
• develop in dysplastic milieu
• in some mice with medulloblastoma resulting in hunched posture or head tilt
• severe malformations
• extended at P5
• extensive dysplasia with massive hypercellularity at P14
• dysplastic region contains normal progenitor cells and atypical cuboidal to spindle-shaped cells with indistinct cell borders and scant amount of eosinophilic fibrillar cytoplasm with irregular round to fusiform nuclei
• dysplastic at P28 with more mature cytoarchitecture than at P14 aberrant neuronal and glial organization
• extended at P5
• ectopic progenitor-like cells in the adjacent parenchyma and along the pial surface
• expanded at E15.5
• undefined at P5
• expanded at P14
• with disorganized, entangled glial processes at P5, P14 and P28
• disorganized at P5 and P14
• increased granule neuron precursors cells at P5

behavior/neurological
N
• mice exhibit normal motor coordination
• in some mice with medulloblastoma due to hydrocephaly or nerve impingement
• in mice with medulloblastoma
• in some mice with medulloblastoma resulting in hunched posture or head tilt

neoplasm
N
• mice rarely develop tumors
• beginning at 2 months and increasing incidence with age
• develop in dysplastic milieu

craniofacial
• protruding head in mice with medulloblastoma

growth/size/body
• protruding head in mice with medulloblastoma
• in mice with medulloblastoma

cellular
• radial glial cells in the cerebella exhibit disorganized, entangled glial processes at P5, P14 and P28
• impaired migration of granule neuron precursors in the cerebellum
• increased granule neuron precursor proliferation at P5, P14 and P28

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:189258


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory