Phenotypes Associated with This Genotype

Genotype
MGI:5445959

• Allelic Composition: Dagla^{Gt(OST288027)Lex}/Dagla^{Gt(OST288027)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:189393 )

• mice exhibit reduced 2-arachidonoylglycerol levels in the cortex, cerebellum, hypothalamus and hippocampus compared with wild-type mice

• mice exhibit reduced anandamide levels in the hippocampus compared with wild-type mice

increased single cell response threshold ( J:189393 )

• pyramidal cells exhibit reduced excitability and fire action potentials at lower frequency than wild-type cells

• cells exhibit higher voltage threshold for action potential firing for input current up to 400 pA and stronger spike frequency adaptation compared with wild-type cells

• pyramidal cells stimulated with 20 Hz fail to suppress the inhibitory postsynaptic potentiation independently of stimulus duration compared with wild-type cells

abnormal CNS synaptic transmission ( J:189393 )

• mice lack depolarization-induced suppression of inhibition (DSI) unlike wild-type mice

• however, GABA synaptic transmission is normal