Mouse Genome Informatics
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    Cftrtm1Eur/Cftrtm1Eur
B6.129P2-Cftrtm1Eur
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
digestive/alimentary system
• ileal crypts are filled with dense mucus material and mucin is trapped in the ileal crypts of the small intestine
• the mucus of the small intestine is attached to the epithelium and is impenetrable to 2 um beads unlike in wild-type mice in which the beads sediment through the mucus and are on the epithelium
• high bicarbonate (NaHCO3) or EDTA treatment normalizes the mucus phenotype of mutants
• increase in the number of goblet cells per crypt
• mutants secrete a denser mucus, with 2.6 times more Muc2 glycoprotein and the small intestine shows increased mucin production

endocrine/exocrine glands
• ileal crypts are filled with dense mucus material and mucin is trapped in the ileal crypts of the small intestine
• the mucus of the small intestine is attached to the epithelium and is impenetrable to 2 um beads unlike in wild-type mice in which the beads sediment through the mucus and are on the epithelium
• high bicarbonate (NaHCO3) or EDTA treatment normalizes the mucus phenotype of mutants

Mouse Models of Human Disease
OMIM IDRef(s)
Cystic Fibrosis; CF 219700 J:189205