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Phenotypes Associated with This Genotype
Genotype
MGI:5445420
Allelic
Composition
Cftrtm1Eur/Cftrtm1Eur
Genetic
Background
B6.129P2-Cftrtm1Eur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm1Eur mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• ileal crypts are filled with dense mucus material and mucin is trapped in the ileal crypts of the small intestine
• the mucus of the small intestine is attached to the epithelium and is impenetrable to 2 um beads unlike in wild-type mice in which the beads sediment through the mucus and are on the epithelium
• high bicarbonate (NaHCO3) or EDTA treatment normalizes the mucus phenotype of mutants
• increase in the number of goblet cells per crypt
• mutants secrete a denser mucus, with 2.6 times more Muc2 glycoprotein and the small intestine shows increased mucin production

endocrine/exocrine glands
• ileal crypts are filled with dense mucus material and mucin is trapped in the ileal crypts of the small intestine
• the mucus of the small intestine is attached to the epithelium and is impenetrable to 2 um beads unlike in wild-type mice in which the beads sediment through the mucus and are on the epithelium
• high bicarbonate (NaHCO3) or EDTA treatment normalizes the mucus phenotype of mutants

Mouse Models of Human Disease
OMIM ID Ref(s)
Cystic Fibrosis; CF 219700 J:189205


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory