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Phenotypes Associated with This Genotype
Genotype
MGI:5445345
Allelic
Composition
Flt3tm1Dgg/Flt3tm1Dgg
Kmt2atm1Clgr/Kmt2a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1Dgg mutation (1 available); any Flt3 mutation (52 available)
Kmt2atm1Clgr mutation (0 available); any Kmt2a mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• median survival is 19 weeks of age

neoplasm
• 89% develop acute myeloid leukemia
• 11% develop B-cell leukemia
• disease is more aggressive than in double heterozygous mutants

hematopoietic system

immune system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:189096


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory