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Phenotypes Associated with This Genotype
Genotype
MGI:5445344
Allelic
Composition
Flt3tm1Dgg/Flt3+
Kmt2atm1Clgr/Kmt2a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1Dgg mutation (1 available); any Flt3 mutation (12 available)
Kmt2atm1Clgr mutation (0 available); any Kmt2a mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• median survival of 49 weeks of age compared to 75-94 weeks of age for wild-type and single heterozygotes

neoplasm
• 100% penetrance of acute leukemia at a median age of 49 weeks
• 70% develop acute myeloid leukemia
• 12% develop unclassifiable acute leukemia
• 9% develop B-cell leukemia
• 9% develop biphenotypic leukemia
• loss of Flt3 heterozygosity is seen in leukemias

hematopoietic system
• presence of more than or equal to 20% blasts in blood and blasts in nonhematopoietic organs, including liver and adrenal glands
• mutants develop leukocytosis

immune system
• mutants develop leukocytosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:189096


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory