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Phenotypes Associated with This Genotype
Genotype
MGI:5444222
Allelic
Composition
Tg(ACTA1-TPM3*M9R)4Hrd/0
Genetic
Background
FVB/NJ-Tg(ACTA1-TPM3*M9R)4Hrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-TPM3*M9R)4Hrd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mice exhibit an increase in the number of slow/fast oxidative fibers compared with wild-type mice
• mice develop nemaline rods in muscles resulting in Z line streaming and disruption of sarcomeric register
• mice develop cytoplasmic bodies and tubular aggregates of the sarcoplasmic reticulum
• the number of fibers containing rods and rod size is different in different muscles
• mice exhibit hypertrophy of fast, glycolytic fibers
• skinner fibers exhibit minor changes in response to strontium sensitivity compared with wild-type fibers
• late onset
• nemaline myopathy

Mouse Models of Human Disease
OMIM ID Ref(s)
Nemaline Myopathy 1; NEM1 609284 J:67596


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory