Mouse Genome Informatics
tg
    Tg(ACTA1-TPM3*M9R)4Hrd/0
FVB/NJ-Tg(ACTA1-TPM3*M9R)4Hrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
muscle
• mice exhibit an increase in the number of slow/fast oxidative fibers compared with wild-type mice
• mice develop nemaline rods in muscles resulting in Z line streaming and disruption of sarcomeric register
• mice develop cytoplasmic bodies and tubular aggregates of the sarcoplasmic reticulum
• the number of fibers containing rods and rod size is different in different muscles
• mice exhibit hypertrophy of fast, glycolytic fibers
• skinner fibers exhibit minor changes in response to strontium sensitivity compared with wild-type fibers
• late onset
• nemaline myopathy

Mouse Models of Human Disease
OMIM IDRef(s)
Nemaline Myopathy 1; NEM1 609284 J:67596