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Phenotypes Associated with This Genotype
Genotype
MGI:5444191
Allelic
Composition
Prss56glcr4/Prss56glcr4
Genetic
Background
C57BL/6J-Prss56glcr4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss56glcr4 mutation (0 available); any Prss56 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the angle is narrow and the iris is closely apposed to the trabecular meshwork
• focally hypoplastic with substantially reduced collagen fibrils in the trabecular beams and an increase in open spaces lacking extracellular matrix
• in some mice at 3 months of age
• variable decrease (ranging from 0-10% shorter than in controls) in axial length at 2 months of age
• in severely affected mice
• Background Sensitivity: reduction in axial length is more severe in mice on an inbred C3H/HeA background than in mice on a C57BL/6 background
• focal regions with abnormal crowding of collagen fibrils
• expanded and thicker by as early as 2 months of age
• pupil dilation induces a large increase in intraocular pressure

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
isolated microphthalmia 6 DOID:0060835 OMIM:613517
J:188765


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory