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Phenotypes Associated with This Genotype
Genotype
MGI:5444190
Allelic
Composition
Prss56glcr4/Prss56glcr4
Genetic
Background
involves: C3H/HeA * C57BL/6J * C57BL/LiA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss56glcr4 mutation (0 available); any Prss56 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• develop glaucomatous neurodegeneration characterized by retinal ganglion cell death following the increase in intraocular pressure
• develop glaucomatous neurodegeneration characterized by optic nerve atrophy following the increase in intraocular pressure
• aqueous humor drainage is compromised contributing to the increase in intraocular pressure
• detected in around 50% of mice at 3 months of age and around 90% of mice at 12 months of age

nervous system
• develop glaucomatous neurodegeneration characterized by retinal ganglion cell death following the increase in intraocular pressure
• develop glaucomatous neurodegeneration characterized by optic nerve atrophy following the increase in intraocular pressure

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
isolated microphthalmia 6 DOID:0060835 OMIM:613517
J:188765


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory