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Phenotypes Associated with This Genotype
Genotype
MGI:5444038
Allelic
Composition
Tg(H2-Kb-Jak2*V617F)2Shmd/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in number of CD41+ cells and Gr-1/Mac1 double-positive cells in the bone marrow and spleen (J:130189)
• decrease in the number of CD71/TER119 double-positive cells (J:130189)
• decrease in the percentage of B220+ B cells in the bone marrow and spleen (J:130189)
• increase in number of CD41+ cells and Gr-1/Mac1 double-positive cells in the bone marrow and spleen (J:130189)
• decrease in the number of CD71/TER119 double-positive cells (J:130189)
• decrease in the percentage of B220+ B cells in the bone marrow and spleen (J:130189)
• increase in numbers of mature myeloid cells in spleen (J:130189)
• femurs exhibit prominent population of maturing myeloid cells (J:130189)
• increase in numbers of mature myeloid cells in spleen (J:130189)
• femurs exhibit prominent population of maturing myeloid cells (J:130189)
• megakaryoctyes of many sizes are clustered and show unusual morphology, including aberrant nuclear-to-cytoplasmic ratio, emperipolesis of neutrophils in megakaryocyte cytoplasm, and bulbous or irregularly folded nuclei (J:130189)
• megakaryoctyes of many sizes are clustered and show unusual morphology, including aberrant nuclear-to-cytoplasmic ratio, emperipolesis of neutrophils in megakaryocyte cytoplasm, and bulbous or irregularly folded nuclei (J:130189)
• femurs exhibit prominent population of maturing myeloid cells with a moderate increase in megakaryocyte numbers (J:130189)
• femurs exhibit prominent population of maturing myeloid cells with a moderate increase in megakaryocyte numbers (J:130189)
• decrease in the percentage of erythroid precursor cells in the bone marrow (J:130189)
• decrease in the percentage of erythroid precursor cells in the bone marrow (J:130189)
• decrease in the percentage of erythroblasts in spleen (J:130189)
• decrease in the percentage of erythroblasts in spleen (J:130189)
• number of red blood cells is decreased at 1 month of age with the greatest decrease at 9 months of age (J:130189)
• number of red blood cells is decreased at 1 month of age with the greatest decrease at 9 months of age (J:130189)
• hematocrit is decreased at 1 month of age, with a further decrease at 6 months (J:130189)
• hematocrit is decreased at 1 month of age, with a further decrease at 6 months (J:130189)
• peripheral blood shows giant platelets (J:130189)
• peripheral blood shows giant platelets (J:130189)
• thrombocytosis is seen at 1 months of age, however platelet counts slowly decline with age and return to near-normal levels at 8 months of age (J:130189)
• thrombocytosis is seen at 1 months of age, however platelet counts slowly decline with age and return to near-normal levels at 8 months of age (J:130189)
• mutants exhibit severe leukocytosis at 1 month of age; leukocyte numbers increase with age, with leukocytosis peaking at 5 months of age and then slightly decreasing afterwards but still remaining higher than in controls (J:130189)
• mutants exhibit severe leukocytosis at 1 month of age; leukocyte numbers increase with age, with leukocytosis peaking at 5 months of age and then slightly decreasing afterwards but still remaining higher than in controls (J:130189)
• majority of increased leukocytes are mature neutrophils with some immature cells (J:130189)
• increase in the percentage of neutrophil precursor cells in the bone marrow (J:130189)
• majority of increased leukocytes are mature neutrophils with some immature cells (J:130189)
• increase in the percentage of neutrophil precursor cells in the bone marrow (J:130189)
• complete effacement of normal splenic architecture, with invasion of non-lymphoid cells (J:130189)
• complete effacement of normal splenic architecture, with invasion of non-lymphoid cells (J:130189)
• the red pulp is expanded by an atypical population of maturing myeloid cells and megakaryocytes and few erythroblasts (J:130189)
• the red pulp is expanded by an atypical population of maturing myeloid cells and megakaryocytes and few erythroblasts (J:130189)
• splenomegaly is seen at 3-5 months of age (J:130189)
• splenomegaly is seen at 3-5 months of age (J:130189)
• fibrosis in the spleen, with mild accumulation of fibers at 6 months of age and development of fibrosis by 9 months of age (J:130189)
• fibrosis in the spleen, with mild accumulation of fibers at 6 months of age and development of fibrosis by 9 months of age (J:130189)

immune system
• increase in numbers of mature myeloid cells in spleen (J:130189)
• femurs exhibit prominent population of maturing myeloid cells (J:130189)
• increase in numbers of mature myeloid cells in spleen (J:130189)
• femurs exhibit prominent population of maturing myeloid cells (J:130189)
• mutants exhibit severe leukocytosis at 1 month of age; leukocyte numbers increase with age, with leukocytosis peaking at 5 months of age and then slightly decreasing afterwards but still remaining higher than in controls (J:130189)
• mutants exhibit severe leukocytosis at 1 month of age; leukocyte numbers increase with age, with leukocytosis peaking at 5 months of age and then slightly decreasing afterwards but still remaining higher than in controls (J:130189)
• majority of increased leukocytes are mature neutrophils with some immature cells (J:130189)
• increase in the percentage of neutrophil precursor cells in the bone marrow (J:130189)
• majority of increased leukocytes are mature neutrophils with some immature cells (J:130189)
• increase in the percentage of neutrophil precursor cells in the bone marrow (J:130189)
• complete effacement of normal splenic architecture, with invasion of non-lymphoid cells (J:130189)
• complete effacement of normal splenic architecture, with invasion of non-lymphoid cells (J:130189)
• the red pulp is expanded by an atypical population of maturing myeloid cells and megakaryocytes and few erythroblasts (J:130189)
• the red pulp is expanded by an atypical population of maturing myeloid cells and megakaryocytes and few erythroblasts (J:130189)
• splenomegaly is seen at 3-5 months of age (J:130189)
• splenomegaly is seen at 3-5 months of age (J:130189)
• fibrosis in the spleen, with mild accumulation of fibers at 6 months of age and development of fibrosis by 9 months of age (J:130189)
• fibrosis in the spleen, with mild accumulation of fibers at 6 months of age and development of fibrosis by 9 months of age (J:130189)

skeleton
• mutants develop fibrosis in the bone marrow with age (J:130189)
• mutants develop fibrosis in the bone marrow with age (J:130189)
• bone cortical thickness is mildly increased, with newly formed bony trabeculae, in 6 month old mice (J:130189)
• bone cortical thickness is mildly increased, with newly formed bony trabeculae, in 6 month old mice (J:130189)

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelofibrosis 254450 J:130189


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory