Mouse Genome Informatics
ht
    DccTg(H2-Kb-Jak2*V617F)1Shmd/Dcc+
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• increase in number of CD41+ cells and Gr-1/Mac1 double-positive cells in the bone marrow and spleen
• decrease in the percentage of B220+ B cells in the bone marrow and spleen
• 8 of 43 mutants show polycythemia at 3 months of age
• decrease in the percentage of erythroid precursor cells in the bone marrow
• increase in the percentage of erythroblasts in spleen
• 15 of 43 mutants exhibit leukocytosis, with a predominance of granulocytes
• 2 of 8 mutants with polycythemia and 9 of 15 mutants with thromobocytosis exhibit leukocytosis
• granulocytosis after 4 months of age
• increase in the percentage of neutrophil precursor cells in the bone marrow
• increase in numbers of mature myeloid cells in spleen
• femurs exhibit hypercellular bone marrow with maturing myeloid cells, erythrocytes in many stages of differentiation, and mature megakaryocytes
• emperipolesis of neutrophils in megakaryocyte cytoplasm is seen
• megakaryocytes in the spleen are large in size and have multilobulated nuclei
• 15 of 43 mutants exhibit thrombocytosis
• increase in the number of megakaryocytes in the bone marrow
• architecture of spleen is barely preserved
• red pulp is expanded due to invasion by non-lymphoid cells, megakaryocytes, erythroblasts, and maturing myeloid cells
• splenomegaly is seen at 3-5 months of age in some mutants
• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis

immune system
• 15 of 43 mutants exhibit leukocytosis, with a predominance of granulocytes
• 2 of 8 mutants with polycythemia and 9 of 15 mutants with thromobocytosis exhibit leukocytosis
• granulocytosis after 4 months of age
• increase in the percentage of neutrophil precursor cells in the bone marrow
• increase in numbers of mature myeloid cells in spleen
• architecture of spleen is barely preserved
• red pulp is expanded due to invasion by non-lymphoid cells, megakaryocytes, erythroblasts, and maturing myeloid cells
• splenomegaly is seen at 3-5 months of age in some mutants
• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis

Mouse Models of Human Disease
OMIM IDRef(s)
Polycythemia Vera; PV 263300 J:130189
Thrombocythemia 3; THCYT3 614521 J:130189