Mouse Genome Informatics
hm
    Npr2pwe/Npr2pwe
involves: C3H/HeJ * C57BL/6 * NAW/WI
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: number of homozygotes produced from a heterozygote x heterozygote mating is less than the expected Mendelian ratio (12% vs. 25%)

growth/size/body
• weight is 54% of controls
• crown-rump length is 77% of controls
• dwarfism is evident by 2 weeks of age

limbs/digits/tail

craniofacial
• malocculusion is frequent, but not completely penetrant

reproductive system
• oocytes progress prematurely through meiosis
• all oocytes examined underwent premature germinal vesicle breakdown (GVBD)
• following ovulation, oocytes undergo fragmentation
• vaginal opening occurs at P33-P84
• males are sub-fertile, however, there are no obvious abnormalities in penian bone or testes histology

skeleton
• malocculusion is frequent, but not completely penetrant
• reduction in height of proliferative zone of the tibial growth plate
• reduction in height of hypertrophic zone of the tibial growth plate
• C2 vertebrae have a notch on the dorsal side
• bones formed through endochrondral ossification are reduced in length, however there is no reduction in the width of the skull, femur or ribs

Mouse Models of Human Disease
OMIM IDRef(s)
Acromesomelic Dysplasia, Maroteaux Type; AMDM 602875 J:188839