About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5443996
Allelic
Composition
Npr2pwe/Npr2pwe
Genetic
Background
involves: C3H/HeJ * C57BL/6 * NAW/WI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2pwe mutation (1 available); any Npr2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: number of homozygotes produced from a heterozygote x heterozygote mating is less than the expected Mendelian ratio (12% vs. 25%)

growth/size/body
• weight is 54% of controls
• crown-rump length is 77% of controls
• dwarfism is evident by 2 weeks of age

limbs/digits/tail

craniofacial
• malocculusion is frequent, but not completely penetrant

reproductive system
• oocytes progress prematurely through meiosis
• all oocytes examined underwent premature germinal vesicle breakdown (GVBD)
• following ovulation, oocytes undergo fragmentation
• vaginal opening occurs at P33-P84
• males are sub-fertile, however, there are no obvious abnormalities in penian bone or testes histology

skeleton
• malocculusion is frequent, but not completely penetrant
• reduction in height of proliferative zone of the tibial growth plate
• reduction in height of hypertrophic zone of the tibial growth plate
• C2 vertebrae have a notch on the dorsal side
• bones formed through endochrondral ossification are reduced in length, however there is no reduction in the width of the skull, femur or ribs

Mouse Models of Human Disease
OMIM ID Ref(s)
Acromesomelic Dysplasia, Maroteaux Type; AMDM 602875 J:188839


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory