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Phenotypes Associated with This Genotype
Genotype
MGI:5443996
Allelic
Composition
Npr2pwe/Npr2pwe
Genetic
Background
involves: C3H/HeJ * C57BL/6 * NAW/WI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2pwe mutation (1 available); any Npr2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: number of homozygotes produced from a heterozygote x heterozygote mating is less than the expected Mendelian ratio (12% vs. 25%) (J:188839)
• Background Sensitivity: number of homozygotes produced from a heterozygote x heterozygote mating is less than the expected Mendelian ratio (12% vs. 25%) (J:188839)

growth/size/body
• weight is 54% of controls (J:188839)
• weight is 54% of controls (J:188839)
• crown-rump length is 77% of controls (J:188839)
• crown-rump length is 77% of controls (J:188839)
• dwarfism is evident by 2 weeks of age (J:188839)
• dwarfism is evident by 2 weeks of age (J:188839)

limbs/digits/tail

craniofacial
• malocculusion is frequent, but not completely penetrant (J:188839)
• malocculusion is frequent, but not completely penetrant (J:188839)

reproductive system
• oocytes progress prematurely through meiosis (J:188839)
• all oocytes examined underwent premature germinal vesicle breakdown (GVBD) (J:188839)
• following ovulation, oocytes undergo fragmentation (J:188839)
• oocytes progress prematurely through meiosis (J:188839)
• all oocytes examined underwent premature germinal vesicle breakdown (GVBD) (J:188839)
• following ovulation, oocytes undergo fragmentation (J:188839)
• vaginal opening occurs at P33-P84 (J:188839)
• vaginal opening occurs at P33-P84 (J:188839)
• males are sub-fertile, however, there are no obvious abnormalities in penian bone or testes histology (J:188839)
• males are sub-fertile, however, there are no obvious abnormalities in penian bone or testes histology (J:188839)

skeleton
• malocculusion is frequent, but not completely penetrant (J:188839)
• malocculusion is frequent, but not completely penetrant (J:188839)
• reduction in height of proliferative zone of the tibial growth plate (J:188839)
• reduction in height of proliferative zone of the tibial growth plate (J:188839)
• reduction in height of hypertrophic zone of the tibial growth plate (J:188839)
• reduction in height of hypertrophic zone of the tibial growth plate (J:188839)
• C2 vertebrae have a notch on the dorsal side (J:188839)
• C2 vertebrae have a notch on the dorsal side (J:188839)
• bones formed through endochrondral ossification are reduced in length, however there is no reduction in the width of the skull, femur or ribs (J:188839)
• bones formed through endochrondral ossification are reduced in length, however there is no reduction in the width of the skull, femur or ribs (J:188839)

Mouse Models of Human Disease
OMIM ID Ref(s)
Acromesomelic Dysplasia, Maroteaux Type; AMDM 602875 J:188839


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory