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Phenotypes Associated with This Genotype
Genotype
MGI:5442773
Allelic
Composition
Tph2tm1Pasq/Tph2tm1.1Pasq
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2tm1.1Pasq mutation (0 available); any Tph2 mutation (26 available)
Tph2tm1Pasq mutation (0 available); any Tph2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal density of serotonergic fibers in the cerebral cortex
• reduced innervation, reduced fiber density
• arborization of fibers appears normal at birth but fiber density is significantly lower at 5 days of age
• reduced innervation, reduced fiber density
• arborization of fibers appears normal at birth but fiber density is significantly lower at 5 days of age
• increased density of serotonergic fibers in the nucleus accumbens shell
• hyperinnervation in the hippocampus in all layers, particularly in the ventral portion of each layer


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory