Phenotypes Associated with This Genotype

Genotype
MGI:5442773

• Allelic Composition: Tph2^tm1Pasq/Tph2^tm1.1Pasq
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:188987 )

N • normal density of serotonergic fibers in the cerebral cortex

abnormal paraventricular hypothalamic nucleus morphology ( J:188987 )

• reduced innervation, reduced fiber density

• arborization of fibers appears normal at birth but fiber density is significantly lower at 5 days of age

abnormal suprachiasmatic nucleus morphology ( J:188987 )

• reduced innervation, reduced fiber density

• arborization of fibers appears normal at birth but fiber density is significantly lower at 5 days of age

abnormal hippocampus morphology ( J:188987 )

• increased density of serotonergic fibers in the nucleus accumbens shell

• hyperinnervation in the hippocampus in all layers, particularly in the ventral portion of each layer