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Phenotypes Associated with This Genotype
Genotype
MGI:5442286
Allelic
Composition
Tg(rTH-Tag)20Dmc/0
Genetic
Background
involves: C57BL/6NTac * DBA/2NTac
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm (J:90323)
• no other organ besides the brain and adrenal glands develop a tumor (J:90323)
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm (J:90323)
• no other organ besides the brain and adrenal glands develop a tumor (J:90323)
• adrenal glands develop tumors resembling neuroblastomas (J:90323)
• adrenal glands develop tumors resembling neuroblastomas (J:90323)
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months (J:90323)
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem (J:90323)
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head (J:90323)
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months (J:90323)
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem (J:90323)
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head (J:90323)

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:90323


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory