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Phenotypes Associated with This Genotype
Genotype
MGI:5442286
Allelic
Composition
Tg(rTH-Tag)20Dmc/0
Genetic
Background
involves: C57BL/6NTac * DBA/2NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

endocrine/exocrine glands
• adrenal glands develop tumors resembling neuroblastomas

neoplasm
• adrenal glands develop tumors resembling neuroblastomas
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:90323


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory