Phenotypes Associated with This Genotype

Genotype
MGI:5442286

• Allelic Composition: Tg(rTH-Tag)20Dmc/0
• Genetic Background: involves: C57BL/6NTac * DBA/2NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:90323 )

• adrenal glands develop tumors resembling neuroblastomas

nervous system

increased neuroblastoma incidence ( J:90323 )

• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm

• no other organ besides the brain and adrenal glands develop a tumor

increased brain tumor incidence ( J:90323 )

• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months

• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem

• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

neoplasm

increased adrenal gland tumor incidence ( J:90323 )

• adrenal glands develop tumors resembling neuroblastomas

increased neuroblastoma incidence ( J:90323 )

• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm

• no other organ besides the brain and adrenal glands develop a tumor

increased brain tumor incidence ( J:90323 )

• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months

• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem

• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769	OMIM:256700 OMIM:613013 OMIM:613015 OMIM:613016	J:90323