endocrine/exocrine glands
• adrenal glands develop tumors resembling neuroblastomas
|
nervous system
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
|
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head
|
neoplasm
• adrenal glands develop tumors resembling neuroblastomas
|
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
|
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
neuroblastoma | DOID:769 |
OMIM:256700 OMIM:613013 OMIM:613015 OMIM:613016 |
J:90323 |