Mouse Genome Informatics
tg
    Tg(rTH-Tag)20Dmc/0
involves: C57BL/6NTac * DBA/2NTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• adrenal glands develop tumors resembling neuroblastomas
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

Mouse Models of Human Disease
OMIM IDRef(s)
Neuroblastoma, Susceptibility to 256700 J:90323