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Phenotypes Associated with This Genotype
Genotype
MGI:5441547
Allelic
Composition
Tg(Ins2-Tag*,-flpe)#Gne/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean and median survival are 13.7 weeks

neoplasm
• angiogenic islets are detected from 7 weeks of age
• solid tumors are detected starting at about 10 weeks of age
• mean tumor burden increases linearly with age
• anti-VEGF, but not sunitinib, treatment significantly decreases the number of grossly visible solid tumors after 21 days of treatment
• micro- and macro-invasive carcinomas are detected

endocrine/exocrine glands
• hemorrhagic spots are seen in the pancreas starting at about 7 weeks of age
• angiogenic islets are detected from 7 weeks of age
• solid tumors are detected starting at about 10 weeks of age
• mean tumor burden increases linearly with age
• anti-VEGF, but not sunitinib, treatment significantly decreases the number of grossly visible solid tumors after 21 days of treatment
• micro- and macro-invasive carcinomas are detected

cardiovascular system
• hemorrhagic spots are seen in the pancreas starting at about 7 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:187012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory