Mouse Genome Informatics
ht
    Gata4tm1.2Wtp/Gata4+
B6.Cg-Gata4tm1.2Wtp
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• nearly half of mice die within 1 day of birth

respiratory system
• dilated distal airways and patchy thickening of mesenchyme in some newborn mice
• some mice exhibit reduced artery density in the proximal airways compared with wild-type mice
• enlarged in some mice
• dilated distal airways in 7 of 21 mice between P1 and P8, more pronounced in accessory and middle lobes of the right lung

cardiovascular system
• some mice exhibit reduced artery density in the proximal airways compared with wild-type mice
• fatal cardiac lesions in some newborn
• in some newborn mice
• in some newborn mice

muscle
• in the ventral midline of some neonatal and adult mice with portions of the hernia sac near but not adherent to the liver contains a mixture of hepatocytes and connective tissue cells
• 3 of 21 mice exhibit overt herniation
• 6 of 21 mice exhibit an abnormal fusion of the central tendon to the liver surface with disorganized collagen bundles unlike in wild-type mice

cellular
• increased apoptosis without an affect on cell proliferation in amuscular diaphragm at E13.5

skeleton
• 6 of 21 mice exhibit an abnormal fusion of the central tendon to the liver surface with disorganized collagen bundles unlike in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Diaphragmatic Hernia, Congenital 142340 J:117367