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Phenotypes Associated with This Genotype
Genotype
MGI:5440925
Allelic
Composition
Wnt7apx-2J/Wnt7apx-2J
Genetic
Background
B6;C3Fe-Wnt7apx-2J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt7apx-2J mutation (1 available); any Wnt7a mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digits on the front paws can be twisted, swollen, fused or missing
• the front legs are set at odd angles to the trunk, in a manner suggestive of flippers, and are usually shorter than normal
• the humerus is generally shorter than normal

skeleton
• the humerus is generally shorter than normal

behavior/neurological
• when raised by the tail homozygotes clasp their hindlegs together rather than splay them
• Due to the shortened, twisted front legs homozygotes have a slightly side-to-side gait

reproductive system

integument
• black bumps are found on the skin of the upper surface of the paws

hearing/vestibular/ear
N
• hearing was assessed by auditory brainsetm response is normal at 1, 3, and 5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fuhrmann syndrome DOID:0090067 OMIM:228930
J:188478


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory