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Phenotypes Associated with This Genotype
Genotype
MGI:5440905
Allelic
Composition
Arfgef2tm1Itl/Arfgef2tm1Itl
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arfgef2tm1Itl mutation (0 available); any Arfgef2 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal cortical plate
• impaired cell-autonomous neuronal motility
• mice with exencephaly exhibit periventricular and subependymal heterotopia and abnormal cortical involutions
• in some mice by E18.5
• periventricular and subependymal heterotopia

growth/size/body
• midline gut closure defects

cellular
• impaired cell-autonomous neuronal motility


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory