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Phenotypes Associated with This Genotype
Genotype
MGI:5440213
Allelic
Composition
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
B6.129-Traf3ip2tm1.1Lix
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• Background Sensitivity: while mutants on the C57BL/6 background develop lupus-like disease, they fail to develop Sjogrens syndrome-like disease as seen in the BALB/c background, showing no signs of enlarged submaxillary glands or elevated serum anti-SSB/La IgG autoantibodies
• mutants exhibit a skewing in the repertoire from T1 to T2/T3 B cells resulting in ratios of T2:T1 and T3:T1 B cells that are increased compared to wild-type mice
• number of B cells in the spleen shows a trend toward a statistical increase compared to controls
• however, number of T cells in the spleen is similar to wild-type
• 16-18 week old mutants exhibit significantly increased numbers of total immature AA4.1+B220+ B cells
• mutants exhibit elevated levels of marginal zone B cells
• however, no increase in the number of follicular mature B cells is seen
• in 32-40 week old mutants
• in 32-40 week old mutants
• in 32-40 week old mutants
• 28-32 week old mutants exhibit hypergammaglobulinemia
• however levels of IgM are normal
• increase in cervical lymph node weight and cellularity in 32-40 week old mutants
• increase in cervical lymph node weight and cellularity in 32-40 week old mutants
• 28-32 week old mutants exhibit elevated levels of serum anti-nuclear autoantibodies (anti-chromatin IgG, anti-histone IgG, and anti-dsDNA IgG)

hematopoietic system
• mutants exhibit a skewing in the repertoire from T1 to T2/T3 B cells resulting in ratios of T2:T1 and T3:T1 B cells that are increased compared to wild-type mice
• number of B cells in the spleen shows a trend toward a statistical increase compared to controls
• however, number of T cells in the spleen is similar to wild-type
• 16-18 week old mutants exhibit significantly increased numbers of total immature AA4.1+B220+ B cells
• mutants exhibit elevated levels of marginal zone B cells
• however, no increase in the number of follicular mature B cells is seen
• in 32-40 week old mutants
• in 32-40 week old mutants
• in 32-40 week old mutants
• 28-32 week old mutants exhibit hypergammaglobulinemia
• however levels of IgM are normal

renal/urinary system
• mutants exhibit elevated IgG deposition within the kidney glomeruli
• however, renal failure is not seen in mutants up to 12 months of age
• kidneys show occasional obstruction of the capillary lumina
• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease

cardiovascular system
• kidneys show occasional obstruction of the capillary lumina


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory