Phenotypes Associated with This Genotype

Genotype
MGI:5439846

• Allelic Composition: Mcm8^tm1.1Geno/Mcm8^tm1.1Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:187623 )

♀ • small with condensed nuclei indicating apoptosis in newborn

decreased oocyte number ( J:187623 )

♀ • small with condensed nuclei indicating apoptosis in newborn

azoospermia ( J:187623 )

♂ • in two-thirds of seminiferous tubules

abnormal male germ cell apoptosis ( J:187623 )

♂

abnormal ovary morphology ( J:187623 )

♀ • disorganized at 8 weeks

absent mature ovarian follicles ( J:187623 )

♀ • ovaries in adult mice are devoid of follicles

impaired ovarian folliculogenesis ( J:187623 )

♀ • only arrested primary follicles are observed

abnormal primary ovarian follicle morphology ( J:187623 )

♀ • at 8 weeks, ovaries contain exclusively malformed primary follicles

small ovary ( J:187623 )

♀ • strongly at 8 weeks

small seminiferous tubules ( J:187623 )

♂

small testis ( J:187623 )

♂ • at 8 to 11 weeks

decreased testis weight ( J:187623 )

♂ • at 8 to 11 weeks

testicular atrophy ( J:187623 )

♂ • at 8 to 11 weeks

increased ovary tumor incidence ( J:187623 )

♀ • many mice develop sex cord stromal tumors associated with endometrial hyperplasia of uterus

increased ovary adenoma incidence ( J:187623 )

♀ • ovarian adenoma in all mice later in life

endometrium hyperplasia ( J:187623 )

♀ • in mice that develop sex cord stromal tumors

arrest of male meiosis ( J:187623 )

♂ • block in prophase I

female infertility ( J:187623 )

♀

male infertility ( J:187623 )

♂

cellular

abnormal oocyte morphology ( J:187623 )

♀ • small with condensed nuclei indicating apoptosis in newborn

decreased oocyte number ( J:187623 )

♀ • small with condensed nuclei indicating apoptosis in newborn

azoospermia ( J:187623 )

♂ • in two-thirds of seminiferous tubules

abnormal cell nucleus morphology ( J:187623 )

• micronuclei in mouse embryonic fibroblasts

polyploidy ( J:187623 )

• 4n in some mouse embryonic fibroblasts

increased cellular sensitivity to gamma-irradiation ( J:187623 )

• in mouse embryonic fibroblasts

abnormal male germ cell apoptosis ( J:187623 )

♂

decreased fibroblast proliferation ( J:187623 )

• of mouse embryonic fibroblasts

abnormal double-strand DNA break repair ( J:187623 )

♂ • spermatocytes exhibit a block to homologous recombination double-strand break repair

abnormal DNA replication ( J:187623 )

• mouse embryonic fibroblasts exhibit hypersensitivity to replication fork stress

spontaneous chromosome breakage ( J:187623 )

• broken or aberrant chromosomes in mouse embryonic fibroblasts

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:187623 )

♂ • spermatocytes exhibit a block to homologous recombination double-strand break repair

abnormal DNA replication ( J:187623 )

• mouse embryonic fibroblasts exhibit hypersensitivity to replication fork stress

neoplasm

increased ovary tumor incidence ( J:187623 )

♀ • many mice develop sex cord stromal tumors associated with endometrial hyperplasia of uterus

increased ovary adenoma incidence ( J:187623 )

♀ • ovarian adenoma in all mice later in life

endocrine/exocrine glands

abnormal ovary morphology ( J:187623 )

♀ • disorganized at 8 weeks

absent mature ovarian follicles ( J:187623 )

♀ • ovaries in adult mice are devoid of follicles

impaired ovarian folliculogenesis ( J:187623 )

♀ • only arrested primary follicles are observed

abnormal primary ovarian follicle morphology ( J:187623 )

♀ • at 8 weeks, ovaries contain exclusively malformed primary follicles

small ovary ( J:187623 )

♀ • strongly at 8 weeks

small seminiferous tubules ( J:187623 )

♂

small testis ( J:187623 )

♂ • at 8 to 11 weeks

decreased testis weight ( J:187623 )

♂ • at 8 to 11 weeks

testicular atrophy ( J:187623 )

♂ • at 8 to 11 weeks

increased ovary tumor incidence ( J:187623 )

♀ • many mice develop sex cord stromal tumors associated with endometrial hyperplasia of uterus

increased ovary adenoma incidence ( J:187623 )

♀ • ovarian adenoma in all mice later in life