Analysis Tools
cardiovascular system
|
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice
|
|
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit increased right ventricular systolic pressure compared to wild-type mice with the same treatment, indicating increased sensitivity to stress-induced pulmonary hypertension
• however, mutants exhibit normal right ventricular systolic pressure and do not develop pulmonary hypertension spontaneously under unstressed conditions
|
|
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction
|
immune system
|
• minor increase in adhesion of leukocytes to the vessel wall in the lungs
|
mortality/aging
|
• about 20% fewer than the expected number of heterozygous mice were detected, indicating loss in early development
• most mice that do not survive, die in utero, although some die in the immediate postnatal stage
|
muscle
|
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction
|
respiratory system
|
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice
|
hematopoietic system
|
• minor increase in adhesion of leukocytes to the vessel wall in the lungs
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary pulmonary hypertension | DOID:14557 |
OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344 |
J:117167 | |
