Mouse Genome Informatics
ht
    Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit increased right ventricular systolic pressure compared to wild-type mice with the same treatment, indicating increased sensitivity to stress-induced pulmonary hypertension
• however, mutants exhibit normal right ventricular systolic pressure and do not develop pulmonary hypertension spontaneously under unstressed conditions

immune system
• minor increase in adhesion of leukocytes to the vessel wall in the lungs

mortality/aging
• about 20% fewer than the expected number of heterozygous mice were detected, indicating loss in early development
• most mice that do not survive, die in utero, although some die in the immediate postnatal stage

muscle
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction

respiratory system
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice

hematopoietic system
• minor increase in adhesion of leukocytes to the vessel wall in the lungs

Mouse Models of Human Disease
OMIM IDRef(s)
Pulmonary Hypertension, Primary, 1; PPH1 178600 J:117167