Phenotypes Associated with This Genotype

Genotype
MGI:5438702

• Allelic Composition: Ank1^MRI23420/Ank1^MRI23420
• Genetic Background: SJL/J-Ank1^MRI23420

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Microcytosis in Ank1^MRI23420/Ank1⁺ mice and spherocytosis and jaundice in Ank1^MRI23420/Ank1^MRI23420 mice

mortality/aging

neonatal lethality, incomplete penetrance ( J:187820 )

• fewer than expected mice are born indicating partial neonatal or prenatal lethality

• mice die between 12 and 48 hours after birth

postnatal lethality, complete penetrance ( J:187820 )

• mice die between 12 and 48 hours after birth

prenatal lethality, incomplete penetrance ( J:187820 )

• fewer than expected mice are born indicating partial neonatal or prenatal lethality

hematopoietic system

enlarged spleen ( J:187820 )

increased spleen weight ( J:187820 )

abnormal erythrocyte morphology ( J:187820 )

• severe fragmentation

poikilocytosis ( J:187820 )

• amorphous

spherocytosis ( J:187820 )

liver/biliary system

jaundice ( J:187820 )

immune system

enlarged spleen ( J:187820 )

increased spleen weight ( J:187820 )

growth/size/body

enlarged spleen ( J:187820 )

increased spleen weight ( J:187820 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malaria		DOID:12365		J:187820