Phenotypes Associated with This Genotype

Genotype
MGI:5438098

• Allelic Composition: Steap4^tm1Dgen/Steap4^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:187736 )

• slightly by 16 weeks and increased at 20 weeks

decreased circulating insulin level ( J:187736 )

• at 12 weeks and increased at 20 weeks

increased circulating leptin level ( J:187736 )

• at 12 weeks

abnormal circulating cholesterol level ( J:187736 )

• total cholesterol at 12 weeks

increased circulating triglyceride level ( J:187736 )

• at 12 weeks

abnormal gluconeogenesis ( J:187736 )

• under basal and clamp conditions, hepatic glucose production is increased compared to in wild-type mice

impaired glucose tolerance ( J:187736 )

insulin resistance ( J:187736 )

increased liver triglyceride level ( J:187736 )

• at 6 months

abnormal metabolism ( J:187736 )

• lower metabolic rate

adipose tissue

abnormal white adipose tissue morphology ( J:187736 )

• visceral white adipose tissue exhibit increased number of mononuclear cells (macrophage) among adipocytes unlike in wild-type mice

• however, subcutaneous adipose tissue do not exhibit accumulation of mononuclear cells

increased subcutaneous adipose tissue amount ( J:187736 )

• by 5 months

decreased adipocyte glucose uptake ( J:187736 )

• impaired

behavior/neurological

decreased locomotor activity ( J:187736 )

• particularly during the dark cycle

cellular

decreased adipocyte glucose uptake ( J:187736 )

• impaired

decreased muscle cell glucose uptake ( J:187736 )

• impaired

oxidative stress ( J:187736 )

• increased lipid peroxidation in visceral white adipose tissue indicating increased susceptibility to oxidative stress

integument

increased subcutaneous adipose tissue amount ( J:187736 )

• by 5 months

hematopoietic system

increased macrophage cell number ( J:187736 )

• in the visceral white adipose tissue

liver/biliary system

increased liver weight ( J:187736 )

increased liver triglyceride level ( J:187736 )

• at 6 months

hepatic steatosis ( J:187736 )

• particularly as mice age

muscle

decreased muscle cell glucose uptake ( J:187736 )

• impaired

immune system

increased macrophage cell number ( J:187736 )

• in the visceral white adipose tissue

growth/size/body

increased liver weight ( J:187736 )