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Phenotypes Associated with This Genotype
Genotype
MGI:5438092
Allelic
Composition
Btbd9Gt(RRE078)Byg/Btbd9Gt(RRE078)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9Gt(RRE078)Byg mutation (0 available); any Btbd9 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• paired pulse ratios at three different inter-stimulus intervals are enhanced suggesting a defect in short term plasticity
• enhanced long term potentiation suggests a defect in long term plasticity
• paired pulse ratios at three different inter-stimulus intervals are enhanced
• suggesting a defect in long term plasticity
• decreased frequency and amplitude but no changes in rise or decay times

behavior/neurological
• travel a greater distance in an open field assay
• increase in activity when placed in constant darkness but significant alterations in circadian rhythms
• increase in counterclockwise circling but no difference in clockwise circling
• decrease in response time to a warm stimulus in a tail flick assay
• treatment with ropinirole rescues the sensory alteration
• decrease in slow wave sleep and increase in awake time but no change in REM
• increase in arousals

homeostasis/metabolism
• increase in 5-HIAA, a metabolite of serotonin, in the striatum suggesting an alteration in serotonin metabolism
• however, no alteration in serotonin levels are detected in the striatum

Mouse Models of Human Disease
OMIM ID Ref(s)
Restless Legs Syndrome, Susceptibility to, 6; RLS6 611185 J:187433


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory