Mouse Genome Informatics
hm
    Btbd9Gt(RRE078)Byg/Btbd9Gt(RRE078)Byg
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• paired pulse ratios at three different inter-stimulus intervals are enhanced suggesting a defect in short term plasticity
• enhanced long term potentiation suggests a defect in long term plasticity
• paired pulse ratios at three different inter-stimulus intervals are enhanced
• suggesting a defect in long term plasticity
• decreased frequency and amplitude but no changes in rise or decay times

behavior/neurological
• travel a greater distance in an open field assay
• increase in activity when placed in constant darkness but significant alterations in circadian rhythms
• increase in counterclockwise circling but no difference in clockwise circling
• decrease in response time to a warm stimulus in a tail flick assay
• treatment with ropinirole rescues the sensory alteration
• decrease in slow wave sleep and increase in awake time but no change in REM
• increase in arousals

homeostasis/metabolism
• increase in 5-HIAA, a metabolite of serotonin, in the striatum suggesting an alteration in serotonin metabolism
• however, no alteration in serotonin levels are detected in the striatum

Mouse Models of Human Disease
OMIM IDRef(s)
Restless Legs Syndrome, Susceptibility to, 6; RLS6 611185 J:187433