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Phenotypes Associated with This Genotype
Genotype
MGI:5437710
Allelic
Composition
X/Tg(SERPINC1-SV40)BPbr
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• males exhibit hepatocyte hyperplasia/dysplasia at 4 weeks of age, show nodules corresponding to adenomas from the 12th week of age and diffuse hepatocarcinoma from the 20th week of age (J:84204)
• all mice develop hepatocellular carcinoma by 8 months of age (J:101541)

neoplasm
• tumoral angiogenesis occurs before the development of diffuse hepatocarcinoma, with proliferation, remodeling, and arterialization of hepatic sinusoids
• fused, enlarged sinusoids are present in adenomatous nodules at 16 weeks of age, and when hepatocarcinoma is seen, the architecture of the liver is disrupted with large vascular lakes replacing the sinusoids
• some transformed hepatocytes exhibit an endothelial cell phenotype, suggesting a partial vasculogenic mimicry
• the abnormal angiogenesis seen in hepatocarcinoma is associated with platelet aggregation within vascular endothelial cells derived form the portal tract and sinusoid lumen
• males exhibit hepatocyte hyperplasia/dysplasia at 4 weeks of age, show nodules corresponding to adenomas from the 12th week of age and diffuse hepatocarcinoma from the 20th week of age (J:84204)
• all mice develop hepatocellular carcinoma by 8 months of age (J:101541)

cardiovascular system
• tumoral angiogenesis occurs before the development of diffuse hepatocarcinoma, with proliferation, remodeling, and arterialization of hepatic sinusoids
• fused, enlarged sinusoids are present in adenomatous nodules at 16 weeks of age, and when hepatocarcinoma is seen, the architecture of the liver is disrupted with large vascular lakes replacing the sinusoids
• some transformed hepatocytes exhibit an endothelial cell phenotype, suggesting a partial vasculogenic mimicry
• the abnormal angiogenesis seen in hepatocarcinoma is associated with platelet aggregation within vascular endothelial cells derived form the portal tract and sinusoid lumen

hematopoietic system
• macrophages invade the hepatic tissue before development of tumoral angiogenesis

immune system
• macrophages invade the hepatic tissue before development of tumoral angiogenesis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:84204 , J:101541


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory