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Phenotypes Associated with This Genotype
Genotype
MGI:5437304
Allelic
Composition
Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh
Genetic
Background
B6.129X1-Arl6ip5tm1.2Jwzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl6ip5tm1.2Jwzh mutation (0 available); any Arl6ip5 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Arl6ip5tm1.2Jwzh/Arl6ip5tm1.2Jwzh mice show decreased susceptiblity to DMBA/TPA-induced tumor formation

neoplasm
N
• mice do not exhibit spontaneous tumors
• DMBA/TPA-treated mice develop fewer and smaller skin papillomas compared with control mice
• DMBA/TPA-treated mice develop fewer and smaller skin papillomas due to reduced proliferation compared with control mice

skeleton

integument
• keratinocytes exhibit enhanced DMBA-induced DNA damage compared with control cells

growth/size/body

immune system

homeostasis/metabolism
• DMBA/TPA-treated mice develop fewer and smaller skin papillomas compared with control mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory