About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5437224
Allelic
Composition
Sox7tm1.1Dsco/Sox7+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1.1Dsco mutation (0 available); any Sox7 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in some cases the gallbladder is fused to the underside of the anterior diaphragm
• Background Sensitivity: around 14% of mice (10 of 71, age P28 to adult) on a mixed 129 and C57BL/6 background have congenital diaphragmatic hernia located directly behind the sternum in the ventral midline; hernias are not seen in mice on a congenic C57BL/6 background
• in severe cases the gallbladder and a pedunculated portion of the liver are found in the thoracic cavity

liver/biliary system
• in some cases the gallbladder is fused to the underside of the anterior diaphragm

endocrine/exocrine glands
• in some cases the gallbladder is fused to the underside of the anterior diaphragm

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital diaphragmatic hernia DOID:3827 OMIM:142340
OMIM:222400
OMIM:610187
J:187416


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory