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Phenotypes Associated with This Genotype
Genotype
MGI:5437224
Allelic
Composition
Sox7tm1.1Dsco/Sox7+
Genetic
Background
involves: 129/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1.1Dsco mutation (0 available); any Sox7 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in some cases the gallbladder is fused to the underside of the anterior diaphragm
• Background Sensitivity: around 14% of mice (10 of 71, age P28 to adult) on a mixed 129 and C57BL/6 background have congenital diaphragmatic hernia located directly behind the sternum in the ventral midline; hernias are not seen in mice on a congenic C57BL/6 background
• in severe cases the gallbladder and a pedunculated portion of the liver are found in the thoracic cavity

liver/biliary system
• in some cases the gallbladder is fused to the underside of the anterior diaphragm

endocrine/exocrine glands
• in some cases the gallbladder is fused to the underside of the anterior diaphragm

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:187416


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory