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Phenotypes Associated with This Genotype
Genotype
MGI:5435702
Allelic
Composition
Shank2tm1.1Tmb/Shank2tm1.1Tmb
Genetic
Background
B6.129-Shank2tm1.1Tmb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank2tm1.1Tmb mutation (0 available); any Shank2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
• during the light-dark box test (J:186719)
• during the light-dark box test (J:186719)
• in a 3 chamber test display reduced conspecific recognition or interest in social novelty compared to controls (J:186719)
• in a 3 chamber test display reduced conspecific recognition or interest in social novelty compared to controls (J:186719)
• self-grooming time is increased in females (J:186719)
• self-grooming time is increased in females (J:186719)
• shorter digging bouts (J:186719)
• shorter digging bouts (J:186719)
• in females at P8 compared to heterozygotes (J:186719)
• in females at P8 compared to heterozygotes (J:186719)
• in males at P4 and P10 (J:186719)
• in males at P4 and P10 (J:186719)
• increase in the proportion of mice showing limb grasping at 4 months of age compared to wild-type controls (J:186719)
• increase in the proportion of mice showing limb grasping at 4 months of age compared to wild-type controls (J:186719)
• in an open field assay (J:186719)
• in an open field assay (J:186719)
• latency to first contact is increased during interactions of a mutant male with an estrus C57BL/6 female but duration of contact is similar to controls (J:186719)
• latency to first vocalization is significantly longer and more short and unstructured calls are emitted during interactions of a mutant male with an estrus C57BL/6 female compared to wild-type pairings (J:186719)
• latency to first contact is increased during interactions of a mutant male with an estrus C57BL/6 female but duration of contact is similar to controls (J:186719)
• latency to first vocalization is significantly longer and more short and unstructured calls are emitted during interactions of a mutant male with an estrus C57BL/6 female compared to wild-type pairings (J:186719)
• latency to first contact is similar to controls but time spent investigating mice of the same sex is reduced in both males and females (J:186719)
• latency to first contact is similar to controls but time spent investigating mice of the same sex is reduced in both males and females (J:186719)
• female but not male pups (P4 and P10) call more frequently when isolated compared to age and sex matched controls (J:186719)
• in female - female interactions there is a longer latency to emit the first vocalization and fewer vocalizations in interactions involving one mutant female compared to interactions between wild-type mice (J:186719)
• females utter more short and unstructured calls and fewer mixed calls in mutant-wild-type pairs compared to pairs involving only wild-type mice (J:186719)
• female but not male pups (P4 and P10) call more frequently when isolated compared to age and sex matched controls (J:186719)
• in female - female interactions there is a longer latency to emit the first vocalization and fewer vocalizations in interactions involving one mutant female compared to interactions between wild-type mice (J:186719)
• females utter more short and unstructured calls and fewer mixed calls in mutant-wild-type pairs compared to pairs involving only wild-type mice (J:186719)

nervous system
• slight decrease in dendritic spine numbers in the hippocampus (J:186719)
• slight decrease in dendritic spine numbers in the hippocampus (J:186719)
• field excitatory postsynaptic potentials are decreased by about 40% in CA1 pyramidal cells in acute hippocampal slices from mice at age P21-P28 and 3 months (J:186719)
• field excitatory postsynaptic potentials are decreased by about 40% in CA1 pyramidal cells in acute hippocampal slices from mice at age P21-P28 and 3 months (J:186719)
• long-term potentiation induced by high-frequency stimulation of the Schaffer collaterals is slightly enhanced (J:186719)
• long-term potentiation induced by high-frequency stimulation of the Schaffer collaterals is slightly enhanced (J:186719)
• decrease in frequency in CA1 pyramidal cells but no difference in amplitude (J:186719)
• decrease in frequency in CA1 pyramidal cells but no difference in amplitude (J:186719)

growth/size/body
• in females at 6, 8, and 10 days of age (J:186719)
• in juvenile (20-22 days of age) and adult (4 months of age) males and females (J:186719)
• in females at 6, 8, and 10 days of age (J:186719)
• in juvenile (20-22 days of age) and adult (4 months of age) males and females (J:186719)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, 17; AUTS17 613436 J:186719


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory