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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank2tm1.1Tmb mutation (0 available); any Shank2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

• during the light-dark box test
• in a 3 chamber test display reduced conspecific recognition or interest in social novelty compared to controls
• self-grooming time is increased in females
• in females at P8 compared to heterozygotes
• in males at P4 and P10
• increase in the proportion of mice showing limb grasping at 4 months of age compared to wild-type controls
• in an open field assay
• latency to first contact is increased during interactions of a mutant male with an estrus C57BL/6 female but duration of contact is similar to controls
• latency to first vocalization is significantly longer and more short and unstructured calls are emitted during interactions of a mutant male with an estrus C57BL/6 female compared to wild-type pairings
• latency to first contact is similar to controls but time spent investigating mice of the same sex is reduced in both males and females
• female but not male pups (P4 and P10) call more frequently when isolated compared to age and sex matched controls
• in female - female interactions there is a longer latency to emit the first vocalization and fewer vocalizations in interactions involving one mutant female compared to interactions between wild-type mice
• females utter more short and unstructured calls and fewer mixed calls in mutant-wild-type pairs compared to pairs involving only wild-type mice

nervous system
• slight decrease in dendritic spine numbers in the hippocampus
• field excitatory postsynaptic potentials are decreased by about 40% in CA1 pyramidal cells in acute hippocampal slices from mice at age P21-P28 and 3 months
• long-term potentiation induced by high-frequency stimulation of the Schaffer collaterals is slightly enhanced
• decrease in frequency in CA1 pyramidal cells but no difference in amplitude

• in females at 6, 8, and 10 days of age
• in juvenile (20-22 days of age) and adult (4 months of age) males and females

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, 17; AUTS17 613436 J:186719

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last database update
MGI 6.01
The Jackson Laboratory