Mouse Genome Informatics
hm
    Shank2tm1.1Tmb/Shank2tm1.1Tmb
B6.129-Shank2tm1.1Tmb
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

behavior/neurological
• during the light-dark box test
• in a 3 chamber test display reduced conspecific recognition or interest in social novelty compared to controls
• self-grooming time is increased in females (J:186719)
• in females at P8 compared to heterozygotes (J:186719)
• in males at P4 and P10 (J:186719)
• increase in the proportion of mice showing limb grasping at 4 months of age compared to wild-type controls
• in an open field assay
• latency to first contact is increased during interactions of a mutant male with an estrus C57BL/6 female but duration of contact is similar to controls (J:186719)
• latency to first vocalization is significantly longer and more short and unstructured calls are emitted during interactions of a mutant male with an estrus C57BL/6 female compared to wild-type pairings (J:186719)
• latency to first contact is similar to controls but time spent investigating mice of the same sex is reduced in both males and females
• female but not male pups (P4 and P10) call more frequently when isolated compared to age and sex matched controls (J:186719)
• in female - female interactions there is a longer latency to emit the first vocalization and fewer vocalizations in interactions involving one mutant female compared to interactions between wild-type mice (J:186719)
• females utter more short and unstructured calls and fewer mixed calls in mutant-wild-type pairs compared to pairs involving only wild-type mice (J:186719)

nervous system
• slight decrease in dendritic spine numbers in the hippocampus
• field excitatory postsynaptic potentials are decreased by about 40% in CA1 pyramidal cells in acute hippocampal slices from mice at age P21-P28 and 3 months
• long-term potentiation induced by high-frequency stimulation of the Schaffer collaterals is slightly enhanced
• decrease in frequency in CA1 pyramidal cells but no difference in amplitude

growth/size
• in females at 6, 8, and 10 days of age
• in juvenile (20-22 days of age) and adult (4 months of age) males and females

Mouse Models of Human Disease
OMIM IDRef(s)
Autism, Susceptibility to, 17; AUTS17 613436 J:186719