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Phenotypes Associated with This Genotype
Genotype
MGI:5435319
Allelic
Composition
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background
involves: C3H * C57BL/6 * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprdb mutation (11 available); any Lepr mutation (37 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• nonfasting blood glucose levels are elevated compared to control Leprdb heterozygotes (J:186924)
• however, fasting blood glucose is normal at 5-7 weeks of age (J:186924)
• nonfasting blood glucose levels are elevated compared to control Leprdb heterozygotes (J:186924)
• however, fasting blood glucose is normal at 5-7 weeks of age (J:186924)
• nonfasting and fasting hyperinsulinemia (J:186924)
• nonfasting and fasting hyperinsulinemia (J:186924)
• elevation in nonfasting plasma cholesterol levels (J:186924)
• however, fasting cholesterol levels are normal (J:186924)
• elevation in nonfasting plasma cholesterol levels (J:186924)
• however, fasting cholesterol levels are normal (J:186924)
• mutants exhibit decreased insulin sensitivity (J:186924)
• mutants exhibit decreased insulin sensitivity (J:186924)
• mutants exhibit an increase in expression of amyloid beta protein in plasma compared to Leprdb heterozygotes, however they do not show amyloid beta plaques yet at 5-7 weeks of age (J:186924)
• mutants exhibit an increase in expression of amyloid beta protein in plasma compared to Leprdb heterozygotes, however they do not show amyloid beta plaques yet at 5-7 weeks of age (J:186924)

endocrine/exocrine glands
• increase in beta cell mass and beta cell area compared to control Leprdb heterozygotes (J:186924)
• increase in beta cell mass and beta cell area compared to control Leprdb heterozygotes (J:186924)

growth/size/body
N
• body weight is normal at 5-7 weeks of age (J:186924)
• body weight is normal at 5-7 weeks of age (J:186924)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory