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Phenotypes Associated with This Genotype
Genotype
MGI:5433047
Allelic
Composition
Gabra1tm1.1Geh/Gabra1+
Genetic
Background
B6.129(Cg)-Gabra1tm1.1Geh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra1tm1.1Geh mutation (0 available); any Gabra1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• 15% of polyspike-and-wave discharges are associated with visible myoclonic jerks

behavior/neurological
• mice at P120 exhibit a discharge that starts with two or more consecutive spikes and/or waves and occurs with an irregular periodicity and a high frequency, features resembling polyspike-and-wave discharges
• spontaneous polyspike-and-wave discharges are more frequent at P120 than P35
• seizures in P120 mutants occur with a higher probability at shorter latencies after PTZ injection than in wild-type mice
• 15% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• one spontaneous generalized tonic-clonic seizure was recorded in one P120 mouse
• spike wave discharges associate with behavioral arrest and treatment with ethosuximide decreases the incidence of spike wave discharges (J:186685)
• mice exhibit absence-like seizures at P35 and P120 (J:227437)
• Background Sensitivity: heterozygotes on a C57BL/6J congenic background display spike wave discharge events with males having an average of 11 per hour and females having an average of 23 per hour (J:186685)
• mice exhibit abundant spike-wave discharges (SWDs) at P35 and P120 (J:227437)
• each SWD consists of very rhythmic, 6-8 Hz spikes, positive transients, and waves (J:227437)
• SWDs are associated with behavioral arrest (J:227437)

nervous system
• mice at P120 exhibit a discharge that starts with two or more consecutive spikes and/or waves and occurs with an irregular periodicity and a high frequency, features resembling polyspike-and-wave discharges
• spontaneous polyspike-and-wave discharges are more frequent at P120 than P35
• seizures in P120 mutants occur with a higher probability at shorter latencies after PTZ injection than in wild-type mice
• 15% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• one spontaneous generalized tonic-clonic seizure was recorded in one P120 mouse
• spike wave discharges associate with behavioral arrest and treatment with ethosuximide decreases the incidence of spike wave discharges (J:186685)
• mice exhibit absence-like seizures at P35 and P120 (J:227437)
• Background Sensitivity: heterozygotes on a C57BL/6J congenic background display spike wave discharge events with males having an average of 11 per hour and females having an average of 23 per hour (J:186685)
• mice exhibit abundant spike-wave discharges (SWDs) at P35 and P120 (J:227437)
• each SWD consists of very rhythmic, 6-8 Hz spikes, positive transients, and waves (J:227437)
• SWDs are associated with behavioral arrest (J:227437)
• reduction in mIPSC amplitudes and increase in the time course of current decay in P35 and P120 cortices
• even though mIPSCs in cortices are of reduced amplitude, the increase in current decay results in the lack of a significant difference in charge transfer


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory