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Phenotypes Associated with This Genotype
Genotype
MGI:5432346
Allelic
Composition
Tg(Ela1-Myc)160Bri/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die between 2 and 7 months of age

neoplasm
• mutants develop pancreatic tumors; tumor progression begins with a thickening of the pancreas at 1 month of age, the then development of 1-10 firm pale small pancreatic nodules at 1-4 months of age, and excessive tumor burden leading to death begins at 2 months of age
• during tumor development, acinar-like cells eventually replace islet tissue and eventually neoplastic ductal elements arise within acinar cell tumors to progress into mixed or ductal adenocarcinomas
• about 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas
• focal areas of some tumors exhibit squamous metaplasia or adenosquamous carcinoma
• tumors are frequently associated with inflammatory cell infiltrate
• about 50% of tumors exhibit characteristics of acinar cell carcinomas, the remaining 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas
• 1 of 10 mutants exhibit tumors that spread to peritoneal surfaces or the liver

liver/biliary system
• some mutants are jaundiced

endocrine/exocrine glands
• non-tumor portions of the pancreas appear atrophied
• small pancreas in some mutants
• mutants develop pancreatic tumors; tumor progression begins with a thickening of the pancreas at 1 month of age, the then development of 1-10 firm pale small pancreatic nodules at 1-4 months of age, and excessive tumor burden leading to death begins at 2 months of age
• during tumor development, acinar-like cells eventually replace islet tissue and eventually neoplastic ductal elements arise within acinar cell tumors to progress into mixed or ductal adenocarcinomas
• about 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas
• focal areas of some tumors exhibit squamous metaplasia or adenosquamous carcinoma
• tumors are frequently associated with inflammatory cell infiltrate
• about 50% of tumors exhibit characteristics of acinar cell carcinomas, the remaining 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas

digestive/alimentary system
• non-tumor portions of the pancreas appear atrophied

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:76992


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory