Mouse Genome Informatics
cx
    Tg(MMTV-rtTA)1Lach/0
Tg(tetO-IGF1R)1Ramo/0

involves: FVB
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days
• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands
• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma
• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma
• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma

endocrine/exocrine glands
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development
• 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

integument
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development
• 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:121069