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Phenotypes Associated with This Genotype
Genotype
MGI:5432258
Allelic
Composition
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-IGF1R)1Ramo/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days
• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands
• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma
• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma
• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma

endocrine/exocrine glands
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia
• 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad
• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days
• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands
• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma
• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma
• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

integument
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia
• 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad
• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days
• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands
• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma
• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma
• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:121069


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory