Mouse Genome Informatics
cx
    Tg(MMTV-rtTA)1Lach/0
Tg(tetO-IGF1R)1Ramo/0

involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days
• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands
• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma
• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma
• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma

endocrine/exocrine glands
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development (J:121069)
• 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad (J:121069)
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia (J:121069)
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia (J:121069)

integument
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development (J:121069)
• 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad (J:121069)
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia (J:121069)
• 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia (J:121069)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:121069