Phenotypes Associated with This Genotype

Genotype
MGI:5432230

• Allelic Composition: Tg(Dct-Grm1)ESzc/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal melanocyte proliferation ( J:83183 )

• hyperproliferation in the pinnae and tail

hyperpigmentation ( J:83183 )

• pinnae, tail, limbs, around snout, eyelid and submandibular and inguinal lymph nodes

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

increased tail pigmentation ( J:83183 )

• hyperpigmented lesions

neoplasm

increased cutaneous melanoma incidence ( J:83183 )

• flat hyperpigmented lesions develop into raised melanomas on the pinnae and tail

• occasionally on the eye lid

immune system

enlarged inguinal lymph nodes ( J:83183 )

enlarged submandibular lymph nodes ( J:83183 )

cellular

abnormal melanocyte proliferation ( J:83183 )

• hyperproliferation in the pinnae and tail

craniofacial

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

hearing/vestibular/ear

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

integument

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

increased tail pigmentation ( J:83183 )

• hyperpigmented lesions

increased cutaneous melanoma incidence ( J:83183 )

• flat hyperpigmented lesions develop into raised melanomas on the pinnae and tail

• occasionally on the eye lid

limbs/digits/tail

increased tail pigmentation ( J:83183 )

• hyperpigmented lesions

growth/size/body

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:83183