Mouse Genome Informatics
cn
    Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+

involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• seminiferous tubule degeneration is seen by 5 weeks of age (J:186144)
• progressive loss of spermatogenesis and testicular atrophy with reduced testis size (J:186144)

reproductive system
• seminiferous tubule degeneration is seen by 5 weeks of age (J:186144)
• progressive loss of spermatogenesis and testicular atrophy with reduced testis size (J:186144)
(J:186144)

tumorigenesis
• female mutants develop granulosa cell tumors by 6 months of age (J:186144)
• male mutants develop granulosa cell tumors of the testis by 9-13 weeks of age (J:186144)

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:186144