Mouse Genome Informatics
cn
    Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+

involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• seminiferous tubule degeneration is seen by 5 weeks of age
• progressive loss of spermatogenesis and testicular atrophy with reduced testis size

reproductive system
• seminiferous tubule degeneration is seen by 5 weeks of age
• progressive loss of spermatogenesis and testicular atrophy with reduced testis size

tumorigenesis
• female mutants develop granulosa cell tumors by 6 months of age
• male mutants develop granulosa cell tumors of the testis by 9-13 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:186144