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Phenotypes Associated with This Genotype
Genotype
MGI:5432192
Allelic
Composition
Tg(YAC128)55Hay/0
Genetic
Background
FVB/N-Tg(YAC128)55Hay
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no neuronal inclusions are detected at 18 months of age in the cortex or striatum
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type
• decrease in striatal volume at 12 months of age
• volume is increased compared to mice hemizygous for Tg(YAC128)53Hay

behavior/neurological
• late onset, beginning at 9 months of age
• disease progression is slower than in mice hemizygous for Tg(YAC128)53Hay or homozygous mice

cellular
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type

homeostasis/metabolism
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:105723


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory