Mouse Genome Informatics
tg
    Tg(YAC128)55Hay/0
FVB/N-Tg(YAC128)55Hay
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• no neuronal inclusions are detected at 18 months of age in the cortex or striatum (J:105723)
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type
• decrease in striatal volume at 12 months of age
• volume is increased compared to mice hemizygous for Tg(YAC128)53Hay

behavior/neurological
• late onset, beginning at 9 months of age
• disease progression is slower than in mice hemizygous for Tg(YAC128)53Hay or homozygous mice

cellular
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type

homeostasis/metabolism
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:105723