Mouse Genome Informatics
tg
    Tg(YAC72)2511Hay/Tg(YAC72)2511Hay
FVB/N-Tg(YAC72)2511Hay
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• general increase in stress-induced apoptosis in primary cultures of striatal neurons
• in cultured striatal medium spiny neurons in response to mitochondria stress
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

homeostasis/metabolism
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

cellular
• general increase in stress-induced apoptosis in primary cultures of striatal neurons
• in cultured striatal medium spiny neurons in response to mitochondria stress
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:105728