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Phenotypes Associated with This Genotype
Genotype
MGI:5432191
Allelic
Composition
Tg(YAC72)2511Hay/Tg(YAC72)2511Hay
Genetic
Background
FVB/N-Tg(YAC72)2511Hay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(YAC72)2511Hay mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay (J:105728)

homeostasis/metabolism
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay (J:105728)

cellular
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay (J:105728)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:105728


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory