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Phenotypes Associated with This Genotype
Genotype
MGI:5431088
Allelic
Composition
Prkchtm1.2Gasc/Prkchtm1.2Gasc
Prkcqtm1Litt/Prkcqtm1Litt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkchtm1.2Gasc mutation (1 available); any Prkch mutation (40 available)
Prkcqtm1Litt mutation (3 available); any Prkcq mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike in either single homozygote, the ratio of CD4 to CD8 T cells is normal
• mildly impaired when stimulated by anti-CD3 antibodies
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice

hematopoietic system
• mildly impaired when stimulated by anti-CD3 antibodies
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice
• greater than in single knock-out mice

endocrine/exocrine glands
• greater than in single knock-out mice
• greater than in single knock-out mice

cellular
• mildly impaired when stimulated by anti-CD3 antibodies


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory