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Phenotypes Associated with This Genotype
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spg20tm1.1Xen mutation (0 available); any Spg20 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• disorganized at 1 and 4 months in female mice
• 4 month old female mice exhibit an increase in lipid droplet numbers compared with wild-type mice
• however, male mice exhibit normal adipose morphology
• in female mice, but not male mice
• highly variable size
• 1 month old female mice exhibit increased in adipocyte number compared with wild-type mice
• 1 month old female mice

• untreated or treated with oleic acid, mouse embryonic fibroblasts (MEFs) exhibit an increase in lipid droplets compared with wild-type cells
• in MEF and chondrocytes
• MEFs exhibit slow cytokinesis and increased number of divisions compared with wild-type cells
• MEFs exhibit aberrant division
• chondrocytes exhibit impaired cytokinesis compared with wild-type cells
• MEFs migrate further than wild-type mice
• however, migration velocity is normal

• at 12 months
• decreased duration and maximum speed on a rotarod at 4 to 7 months
• in female mice
• progressive
• in the right front leg and bilateral hind limbs of one mouse at 6 months due to mesenchymal cell neoplasm

nervous system
• mice exhibit normal neuromusclular junctions
• increased axon length in cultured cortical neurons
• increased branching in cultured cortical neurons
• however, treatment with spartin rescues dendrite branching

• mice exhibit normal long bones
• chondrocytes exhibit impaired cytokinesis with increased numbers of multinucleated cells compared with wild-type cells


• mesenchymal cell neoplasm in one mouse

Mouse Models of Human Disease
OMIM ID Ref(s)
Spastic Paraplegia 20, Autosomal Recessive; SPG20 275900 J:185987

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory