Phenotypes for Itgb1 MGI:5430793 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Itgb1^tm13.1Ref/Itgb1^tm13.1Ref
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm13.1Ref mutation (0 available); any Itgb1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, complete penetrance ( J:185558 )

• no mice are produced from mating heterozygotes

embryo

abnormal embryo development ( J:185558 )

• at E7.5, mice exhibit malformations including defects in cell polarity, laminin111 deposition and cavitation

absent blastocoele ( J:185558 )

reproductive system

abnormal embryo implantation ( J:185558 )

• lack of implantation chamber at E7.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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