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Phenotypes Associated with This Genotype
Genotype
MGI:5430590
Allelic
Composition
Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0
Genetic
Background
B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lect2tm1Ymg mutation (0 available); any Lect2 mutation (7 available)
Tg(Pklr-Myc)73Ak mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

neoplasm
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
• mutants develop hepatocellular carcinoma
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:184496


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory