Phenotypes for Agtrap MGI:5430520 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Agtrap^Gt(XE129)Byg/Agtrap^Gt(XE129)Byg
Genetic Background	involves: 129P2/OlaHsd

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtrap^Gt(XE129)Byg mutation (0 available); any Agtrap mutation (126 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:185854 )

N	• mice exhibit normal response to angiotensin II infusion

abnormal blood homeostasis ( J:185854 )

• reduced plasma volume

decreased urine pH ( J:185854 )

• ambient but not following administration of acetazolamide

cardiovascular system

hypervolemia ( J:185854 )

increased mean systemic arterial blood pressure ( J:185854 )

increased systemic arterial systolic blood pressure ( J:185854 )

renal/urinary system

decreased urine pH ( J:185854 )

• ambient but not following administration of acetazolamide

polyuria ( J:185854 )

• greater following administration of acetazolamide

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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