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Phenotypes Associated with This Genotype
Genotype
MGI:5429559
Allelic
Composition
Fzd3tm1(FZD3)Lex/Fzd3tm1(FZD3)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd3tm1(FZD3)Lex mutation (0 available); any Fzd3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired learning/memory during trace aversive conditioning
• decreased depressive-like response during tail suspension test

cellular
N
• normal appearing respiratory and ependymal cilia with no evidence of ciliary dysfunction

growth/size/body
N
• situs inversus was not observed

nervous system
• varying degrees of dilation of lateral and third ventricles
• varying degrees of dilation of lateral and third ventricles
• impaired sensorimotor gating

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hydrocephalus DOID:10908 OMIM:123155
OMIM:236600
OMIM:236635
OMIM:307000
OMIM:615219
J:185566


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory