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Phenotypes Associated with This Genotype
Genotype
MGI:5428897
Allelic
Composition		 Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased cholangiocarcinoma incidence ( J:184949 )
• mutants develop invasive intrahepatic cholangiocarcinoma with low penetrance (1 of 8 mutants) and long latency (at 36 weeks of age)
increased liver tumor incidence ( J:254370 )
• mice develop liver tumors at 12 months of age and do not show obvious symptoms up to 18 months of age
• tumors resemble hepatocellular dysplasia

liver/biliary system
increased cholangiocarcinoma incidence ( J:184949 )
• mutants develop invasive intrahepatic cholangiocarcinoma with low penetrance (1 of 8 mutants) and long latency (at 36 weeks of age)
increased liver tumor incidence ( J:254370 )
• mice develop liver tumors at 12 months of age and do not show obvious symptoms up to 18 months of age
• tumors resemble hepatocellular dysplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
intrahepatic cholangiocarcinoma DOID:4928 J:184949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory