mortality/aging
• die around E11
• identical to mice homozygous for Arap3tm1.2Sve
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cardiovascular system
• the capillary network is replaced with a large accumulation of endothelial cells
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• identical to mice homozygous for Arap3tm1.2Sve
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• defect in vascular maturation and remodeling, especially apparent in the midbrain
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• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells
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embryo
• identical to mice homozygous for Arap3tm1.2Sve
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• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells
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• at E10.5
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• defect in labyrinth formation
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• identical to mice homozygous for Arap3tm1.2Sve
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• wrinkled yolk sac at E10.5
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• the primary vascular plexus fails to remodel
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growth/size/body
• at E10.5
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integument
nervous system
• the capillary network is replaced with a large accumulation of endothelial cells
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