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Phenotypes Associated with This Genotype
Genotype
MGI:5428758
Allelic
Composition
Arap3tm1.1Sve/Arap3tm1.2Sve
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arap3tm1.1Sve mutation (0 available); any Arap3 mutation (61 available)
Arap3tm1.2Sve mutation (0 available); any Arap3 mutation (61 available)
Tg(Tek-cre)1Ywa mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die around E11
• identical to mice homozygous for Arap3tm1.2Sve

cardiovascular system
• the capillary network is replaced with a large accumulation of endothelial cells
• identical to mice homozygous for Arap3tm1.2Sve
• defect in vascular maturation and remodeling, especially apparent in the midbrain
• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells

embryo
• identical to mice homozygous for Arap3tm1.2Sve
• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells
• defect in labyrinth formation
• identical to mice homozygous for Arap3tm1.2Sve
• wrinkled yolk sac at E10.5
• the primary vascular plexus fails to remodel

growth/size/body

integument
• at E10.5

nervous system
• the capillary network is replaced with a large accumulation of endothelial cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory