Mouse Genome Informatics
cx
    Tg(Sox3)1Pqt/0
Tg(Sox3-EGFP)NrPqt/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• choroid plexus development is normal (J:184232)
• the fourth ventricle is not enlarged (J:184232)
• formation of diencephalic roof plate is inhibited
• in nearly all mice
• at 3 to 5 weeks
• as early as E18.5
• disorganized at E15.5
• missing at E18.5
• formation of diencephalic roof plate is inhibited
• absent pineal recess and pineal gland at E13.5 and E18.5
• at 3 to 5 weeks

embryogenesis
• formation of diencephalic roof plate is inhibited

craniofacial

cellular
• of subcommissural organ primordium cells at E12.5 without a change in apoptosis

endocrine/exocrine glands
• absent pineal recess and pineal gland at E13.5 and E18.5
• thin at E13.5 with fewer elongated cells
• barely discernable at E14.5
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice
• however, SCO initiation is normal

skeleton

Mouse Models of Human Disease
OMIM IDRef(s)
Hydrocephalus Due to Congenital Stenosis of Aqueduct of Sylvius 236635 J:184232