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Phenotypes Associated with This Genotype
Genotype
MGI:5428462
Allelic
Composition
Tg(Sox3)1Pqt/0
Tg(Sox3-EGFP)NrPqt/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• choroid plexus development is normal (J:184232)
• the fourth ventricle is not enlarged (J:184232)
• choroid plexus development is normal (J:184232)
• the fourth ventricle is not enlarged (J:184232)
• formation of diencephalic roof plate is inhibited (J:184232)
• formation of diencephalic roof plate is inhibited (J:184232)
• thin at E13.5 with fewer elongated cells (J:184232)
• barely discernable at E14.5 (J:184232)
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells (J:184232)
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice (J:184232)
• however, SCO initiation is normal (J:184232)
• thin at E13.5 with fewer elongated cells (J:184232)
• barely discernable at E14.5 (J:184232)
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells (J:184232)
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice (J:184232)
• however, SCO initiation is normal (J:184232)
• in nearly all mice (J:184232)
• in nearly all mice (J:184232)
• as early as E18.5 (J:184232)
• at 3 to 5 weeks (J:184232)
• as early as E18.5 (J:184232)
• at 3 to 5 weeks (J:184232)
• disorganized at E15.5 (J:184232)
• missing at E18.5 (J:184232)
• disorganized at E15.5 (J:184232)
• missing at E18.5 (J:184232)
• formation of diencephalic roof plate is inhibited (J:184232)
• formation of diencephalic roof plate is inhibited (J:184232)
• at E13.5 and E18.5 (J:184232)
• at E13.5 and E18.5 (J:184232)
• at 3 to 5 weeks (J:184232)
• at 3 to 5 weeks (J:184232)
• at E13.5 and E18.5 (J:184232)
• at E13.5 and E18.5 (J:184232)

embryogenesis
• formation of diencephalic roof plate is inhibited (J:184232)
• formation of diencephalic roof plate is inhibited (J:184232)

craniofacial

cellular
• of subcommissural organ primordium cells at E12.5 without a change in apoptosis (J:184232)
• of subcommissural organ primordium cells at E12.5 without a change in apoptosis (J:184232)

endocrine/exocrine glands
• at E13.5 and E18.5 (J:184232)
• at E13.5 and E18.5 (J:184232)
• thin at E13.5 with fewer elongated cells (J:184232)
• barely discernable at E14.5 (J:184232)
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells (J:184232)
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice (J:184232)
• however, SCO initiation is normal (J:184232)
• thin at E13.5 with fewer elongated cells (J:184232)
• barely discernable at E14.5 (J:184232)
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells (J:184232)
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice (J:184232)
• however, SCO initiation is normal (J:184232)

skeleton


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory