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Phenotypes Associated with This Genotype
Genotype
MGI:5428442
Allelic
Composition
Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1tm1Imx
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1.1Doi mutation (2 available); any Aire mutation (20 available)
Il1r1tm1Imx mutation (4 available); any Il1r1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mostly CD4+ T cells
• mice exhibit an increase in acidified conjunctival goblet cells compared with wild-type mice that is not as severe as in Airetm1.1Doi homozygotes
• however, the total number of goblet cells is normal
• mice exhibit ocular mucosal epithelia metaplasia and ocular surface epitheliopathy that is not as severe as in Airetm1.1Doi homozygotes
• progresses from desiccation and keratinization of the ocular surface

immune system
• mostly CD4+ T cells

endocrine/exocrine glands
• mostly CD4+ T cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:163691


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory