Mouse Genome Informatics
cx
    Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1tm1Imx

involves: 129S2/SvPas * 129S7/SvEvBrd * NOD
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• mostly CD4+ T cells
• mice exhibit an increase in acidified conjunctival goblet cells compared with wild-type mice that is not as severe as in Airetm1.1Doi homozygotes
• however, the total number of goblet cells is normal
• mice exhibit ocular mucosal epithelia metaplasia and ocular surface epitheliopathy that is not as severe as in Airetm1.1Doi homozygotes
• progresses from desiccation and keratinization of the ocular surface

immune system
• mostly CD4+ T cells

endocrine/exocrine glands
• mostly CD4+ T cells

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:163691