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Phenotypes Associated with This Genotype
Genotype
MGI:5428306
Allelic
Composition
Tg(Disc1/EGFP)M19Sshe/0
Genetic
Background
involves: C57BL/6JCrl * CBA/CaCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• shorter and fewer neurites than on wild-type neurons
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus
• reduced brain volume and total surface
• 2.3- to 3.0-fold
• 2.26 times and 2.98 times
• partial agenesis
• thin and fails to cross the midline above the subcommissural organ
• shorter and fewer neurites than on wild-type neurons
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus

behavior/neurological
• mice exhibit increased immobility in depression tests compared with wild-type mice
• mice exhibit reduced stress calls during depression tests compared with wild-type mice

cellular
• shorter and fewer neurites than on wild-type neurons
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:143557


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory