Mouse Genome Informatics
tg
    Tg(Disc1/EGFP)M19Sshe/0
involves: C57BL/6JCrl * CBA/CaCrl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• shorter and fewer neurites than on wild-type neurons
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus
• reduced brain volume and total surface
• 2.3- to 3.0-fold
• 2.26 times and 2.98 times
• partial agenesis
• thin and fails to cross the midline above the subcommissural organ
• shorter and fewer neurites than on wild-type neurons
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus

behavior/neurological
• mice exhibit increased immobility in depression tests compared with wild-type mice
• mice exhibit reduced stress calls during depression tests compared with wild-type mice

cellular
• shorter and fewer neurites than on wild-type neurons
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:143557