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Phenotypes Associated with This Genotype
Genotype
MGI:5428306
Allelic
Composition
Tg(Disc1/EGFP)M19Sshe/0
Genetic
Background
involves: C57BL/6JCrl * CBA/CaCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• shorter and fewer neurites than on wild-type neurons (J:143557)
• shorter and fewer neurites than on wild-type neurons (J:143557)
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice (J:143557)
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice (J:143557)
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus (J:143557)
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus (J:143557)
• reduced brain volume and total surface (J:143557)
• reduced brain volume and total surface (J:143557)
• 2.3- to 3.0-fold (J:143557)
• 2.3- to 3.0-fold (J:143557)
• 2.26 times and 2.98 times (J:143557)
• 2.26 times and 2.98 times (J:143557)
• partial agenesis (J:143557)
• thin and fails to cross the midline above the subcommissural organ (J:143557)
• partial agenesis (J:143557)
• thin and fails to cross the midline above the subcommissural organ (J:143557)
• shorter and fewer neurites than on wild-type neurons (J:143557)
• shorter and fewer neurites than on wild-type neurons (J:143557)
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus (J:143557)
• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus (J:143557)

behavior/neurological
• mice exhibit increased immobility in depression tests compared with wild-type mice (J:143557)
• mice exhibit increased immobility in depression tests compared with wild-type mice (J:143557)
• defective (J:143557)
• defective (J:143557)
• mice exhibit reduced stress calls during depression tests compared with wild-type mice (J:143557)
• mice exhibit reduced stress calls during depression tests compared with wild-type mice (J:143557)

cellular
• shorter and fewer neurites than on wild-type neurons (J:143557)
• shorter and fewer neurites than on wild-type neurons (J:143557)
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice (J:143557)
• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice (J:143557)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:143557


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory