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Phenotypes Associated with This Genotype
Genotype
MGI:5427936
Allelic
Composition
Gata4tm1Grg/Gata4+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Grg mutation (1 available); any Gata4 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Atrial septal defects and semilunar valve stenosis in Gata4tm1Grg/Gata4+ mice

cardiovascular system
• in 4 of 12 mutants
• increase in the frequency of mice with intermittent shunting of blood between the atria
• thickened aortic valve leaflets
• in 2 of 12 mutants
• thickened pulmonary valve leaflets

cellular

muscle

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrial Septal Defect 2; ASD2 607941 J:185124


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory