Phenotypes Associated with This Genotype

Genotype
MGI:5427935

• Allelic Composition: Gata4^tm1Grg/Gata4^tm1Grg
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation and a thin myocardium in Gata4^tm1Grg/Gata4^tm1Grg mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185124 )

• die between E10.5 and E11.5

growth/size/body

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

cardiovascular system

thin myocardium ( J:185124 )

• severe thinning at E10.5

delayed heart looping ( J:185124 )

• some embryos show delayed or incomplete looping at E9.5 and E10.5

thin ventricular wall ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

embryo

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

muscle

thin myocardium ( J:185124 )

• severe thinning at E10.5

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5